Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances

Antiparasitic Activities of Acyl Hydrazones from Cinnamaldehydes and Structurally Related Fragrances

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Background: New drugs for the treatment of protozoal parasite infections such as toxoplasmosis and leishmaniasis are required.Cinnamaldehyde and its derivatives appear to be promising antiparasitic drug candidates.Methods: Acyl hydrazones of cinnamaldehyde, 4-dimethylaminocinnamaldehyde, motovox scooter parts and of the synthetic fragrances silvialTM and florhydralTM were prepared and tested for activity against Toxoplasma gondii (T.gondii) and Leishmania major (L.

major) parasites.Results: Three cinnamaldehyde acyl hydrazones (3-hydroxy-2-naphthoyl 2a and the salicyloyls 2c and 2d) showed good activity against T.gondii, and two compounds derived from cinnamaldehyde and florhydralTM (3-hydroxy-2-naphthoyls 2a and 4a) exhibited moderate activity against L.major promastigotes.

Conclusions: In particular, the identified antitoxoplasmal activities are promising and might lead to the arrethe bush balm development of new potent and cost-effective drug candidates for the therapy of toxoplasmosis.